How to Taper Wellbutrin Safely

If you’re thinking about lowering your Wellbutrin (bupropion) dose, you’re not alone. Many people want to stop or reduce the med because of side effects, a change in symptoms, or because they’ve finished a treatment course. Jumping off the pill cold can cause headaches, mood swings, or a return of depression. That’s why a gradual taper works best—it lets your brain adjust without a harsh shock.

Why a Taper is Important

Wellbutrin affects dopamine and norepinephrine, two chemicals that help lift mood and boost energy. When you cut the dose suddenly, those chemicals dip quickly, leading to what feels like a crash. A slow reduction keeps the drop steady, so you experience fewer withdrawal symptoms and stay stable emotionally. Doctors usually recommend a taper when you’ve been on the drug for at least a few weeks and when your dose is 150 mg or higher.

Step‑by‑Step Taper Plan

Here’s a simple schedule you can discuss with your doctor. Adjust the timeline based on how you feel, but keep changes spaced out by at least one to two weeks.

Step 1: If you’re on 300 mg daily, cut to 250 mg for 1‑2 weeks. If you have 150 mg tablets, you might split one and take 75 mg instead.

Step 2: After the first period, lower to 200 mg for another week or two. Monitor your mood, sleep, and energy levels.

Step 3: Drop to 150 mg for 1‑2 weeks. Some people feel fine at this dose; others notice a dip in motivation. Keep a journal of any changes.

Step 4: If you need to go lower, move to 100 mg (half a 150 mg tablet) for a week, then 75 mg, and finally 0 mg. Each step should be taken only when you feel stable.

Never skip a step. If symptoms flare, stay at the current dose longer before lowering again. Staying in touch with your prescriber is key— they can suggest adding a short‑acting antidepressant or a low‑dose sleep aid if needed.

Remember, tapering is a personal process. Some people need a slower pace, especially if they’ve been on Wellbutrin for many months. The goal is to reach the lowest effective dose or stop completely while keeping your mood steady.

Finally, take care of yourself during the taper. Eat balanced meals, stay active, and keep a regular sleep schedule. These habits support your brain’s chemistry and can make the taper smoother. If you notice severe mood swings, thoughts of self‑harm, or intense physical symptoms, contact your doctor right away.