Methotrexate: What It Is and When It’s Used

Methotrexate is a medicine that slows down fast‑growing cells. Doctors prescribe it for rheumatoid arthritis, psoriasis, and several cancers. It works by lowering the immune response, which helps reduce joint pain and swelling. Because it affects cell growth, the dose is much lower for arthritis than for chemotherapy. Knowing the purpose of your prescription helps you follow the plan correctly.

How to Take Methotrexate Safely

First, follow the schedule your doctor gave you – usually once a week, not daily. Taking it more often can cause serious toxicity. If you use a weekly pill, set a reminder on the same day each week to avoid mistakes.

Second, take it with food and plenty of water. This reduces stomach irritation and helps the drug absorb properly. Many doctors also recommend a folic acid supplement; it lessens mouth sores and liver stress.

Third, keep regular lab checks. Blood tests monitor liver enzymes, blood cell counts, and kidney function. If any numbers go out of range, your doctor may adjust the dose or pause treatment.

Fourth, avoid alcohol while on Methotrexate. Alcohol adds extra strain on the liver and can raise the risk of side effects. If you need to drink socially, talk to your doctor about safe limits.

Managing Common Side Effects

Feeling a sore mouth or tongue is common, especially in the first weeks. Rinsing with a mild salt‑water solution and using a soft toothbrush can help. Nausea can be eased by taking the pill with a snack and staying upright for 30 minutes after.

Some people notice fatigue or mild headaches. If these symptoms linger, check with your doctor – sometimes a dose tweak fixes them.

Liver irritation shows up as yellowing of the skin or dark urine. These signs are rare but need immediate medical attention. Regular blood tests catch problems early, so never skip appointments.

Remember to store Methotrexate out of reach of children and pets. Keep it in a locked cabinet and discard any missed doses safely.

Overall, Methotrexate can be a powerful tool when used correctly. Stick to the weekly schedule, take it with food, add folic acid, and keep up with lab work. If you notice side effects, act quickly and talk to your healthcare provider. With these habits, you can manage your condition while minimizing risks.