How to Avoid Out-of-Network Pharmacy Surprises for Medications

How to Avoid Out-of-Network Pharmacy Surprises for Medications
Elara Kingswell 28 November 2025 3 Comments

Imagine this: you walk into your local pharmacy to pick up a life-changing medication. You hand over your insurance card, expect a $20 copay, and then get hit with a $300 bill. No warning. No notice. Just a receipt that makes your stomach drop. This isn’t rare. In fact, 28% of commercially insured adults in the U.S. faced unexpected pharmacy costs in 2022, with over 20% paying more than $500. And here’s the kicker: the No Surprises Act, which stopped surprise medical bills for emergency care, does nothing for prescription drugs.

Why Your Insurance Doesn’t Protect You at the Pharmacy

Most people assume their health plan works the same everywhere - doctor visits, hospital stays, and pharmacies all under one roof. But that’s not how it works. Pharmacy benefits are managed by separate companies called pharmacy benefit managers (PBMs), like CVS Caremark, Express Scripts, or OptumRx. These PBMs create their own networks of pharmacies - completely separate from your medical network.

So you might be covered at your cardiologist’s office, but if you fill your heart medication at a pharmacy that’s not in the PBM’s network, you’re on your own. You could pay 3 to 5 times more than if you’d gone to an in-network pharmacy. And there’s no law forcing the pharmacy to warn you. No federal protection. No cap on what they can charge you at the counter.

How Out-of-Network Pharmacy Costs Work

When you use an out-of-network pharmacy, you’re not getting the negotiated discounts your insurer has locked in. Instead, you pay the full retail price - and sometimes even more. Here’s how it breaks down:

  • In-network pharmacy: You pay your copay - say, $15 for a 30-day supply of metformin.
  • Out-of-network pharmacy: You pay the full price - maybe $180 - and then file a claim hoping for partial reimbursement. Most plans won’t reimburse you fully, if at all.
This isn’t a billing error. It’s how the system is built. The PBM sets the rules, and the pharmacy follows them. If your plan says “only use CVS or Walgreens,” and you go to a local independent pharmacy, you’re outside the network - even if that pharmacy accepts your insurance.

Real Stories, Real Costs

On Reddit, users share stories like:

  • “I paid $320 for my insulin at a pharmacy near my work. At my regular CVS, it’s $35. No one told me the difference.”
  • “My daughter’s specialty medication for juvenile arthritis costs $2,100 out-of-network. The PBM says it’s only covered at one pharmacy - 90 minutes away.”
A 2022 Patient Advocate Foundation report found over 12,400 cases of pharmacy billing disputes, and 89% involved out-of-network charges that patients thought were covered. These aren’t mistakes. They’re systemic gaps.

Person comparing phone screens showing  vs 0 pharmacy prices, with PBM icon blocking protection.

What the No Surprises Act Does - and Doesn’t Do

The No Surprises Act, which took effect in January 2022, was meant to protect you from surprise bills for emergency care, air ambulances, and certain non-emergency services at in-network hospitals. But it explicitly excludes prescription drugs. The Centers for Medicare & Medicaid Services (CMS) confirmed this in a December 2021 fact sheet: “Pharmacy benefits are not covered under the No Surprises Act.”

The Department of Labor, Health and Human Services, and Treasury all issued a joint bulletin in April 2023 reiterating the same thing: “Nothing in the law addresses pharmacy benefits.”

So if you’re expecting the same protections for your pills as you get for your ER visit - you’re out of luck.

How to Avoid Being Caught Off Guard

You can’t rely on luck or assumptions. You have to be proactive. Here’s how:

  1. Check your pharmacy network before you fill any prescription. Don’t just look at your insurance card. Log into your plan’s website or call your PBM directly. Ask: “Which pharmacies are in-network for my prescription drug plan?”
  2. Use the Medicare Plan Finder if you’re on Medicare Part D. It lets you compare pharmacy networks side-by-side. Don’t assume your medical network matches your pharmacy network.
  3. Ask your doctor or pharmacist for the PBM’s network list. Many doctors don’t know the difference between medical and pharmacy networks. Ask them: “Is this medication covered at my local pharmacy, or do I need to go somewhere specific?”
  4. Use your plan’s online tool or app. Most health plans have a “Find a Pharmacy” feature. Use it. Type in the pharmacy’s name and address. If it says “out-of-network,” don’t fill the script there.
  5. Call before you go. If you’re unsure, call the pharmacy and say: “I’m insured through [your plan name]. Is this pharmacy in-network for prescription drugs?” Ask for a confirmation number.
  6. Know your specialty meds. Over 78% of Medicare Part D plans and 65% of commercial plans restrict specialty drugs (like those for MS, cancer, or rheumatoid arthritis) to specific specialty pharmacies. If you’re on one of these, you have zero flexibility.
Floating checklist with icons for checking pharmacy networks, calm person holding small  receipt.

What to Do If You’ve Already Been Hit With a Surprise Bill

If you’ve already paid too much, don’t give up. Here’s what you can do:

  • Request a claim review. Call your PBM and ask for a “reconsideration” of your claim. Sometimes, they’ll retroactively apply in-network pricing if you can prove you didn’t know.
  • Ask for a price match. Show them the in-network price. Many PBMs will adjust your bill if you can prove you paid more than the negotiated rate.
  • File a complaint. Submit a formal complaint to your state’s insurance department. In 2023, California and New York introduced bills to fix this - and public pressure helped.
  • Switch plans during open enrollment. If this keeps happening, look for a plan with a broader pharmacy network next year. Compare networks before you sign up.

The Bigger Picture: Why This Isn’t Getting Fixed

The cost of these surprise pharmacy bills is huge - an estimated $15.3 billion in avoidable out-of-pocket costs in 2022 alone. Yet, there’s no federal law to stop it. Why? Because PBMs are powerful. They negotiate discounts with drug manufacturers and pharmacies, and they profit from the gaps in transparency.

There’s hope, though. The 2023 Consolidated Appropriations Act required real-time benefit checks that should include pharmacy network status - but the rule isn’t fully in place until 2025. The Biden administration allocated $25 million in 2024 to study solutions. And at least 12 states are working on laws to require pharmacy network transparency.

Until then, you’re the only one who can protect yourself.

Bottom Line: Don’t Assume. Verify.

You wouldn’t buy a car without checking the warranty. Don’t fill a prescription without checking the network. Pharmacy surprise bills aren’t accidents - they’re built into the system. The good news? You have the power to avoid them. Just take five minutes before each refill:

  • Check your plan’s pharmacy directory.
  • Call the pharmacy.
  • Ask your pharmacist: “Is this in-network?”
It’s not glamorous. It’s not easy. But it could save you hundreds - or thousands - every year.

Does the No Surprises Act cover out-of-network pharmacy bills?

No. The No Surprises Act protects patients from surprise medical bills for emergency care, air ambulances, and certain non-emergency services at in-network hospitals. It explicitly excludes prescription drug coverage. Pharmacy benefits are managed separately by pharmacy benefit managers (PBMs), and federal law does not require them to limit out-of-network costs.

How do I know if my pharmacy is in-network?

Log into your health plan’s website or app and use the “Find a Pharmacy” tool. You can also call your pharmacy benefit manager (PBM) directly - the number is usually on your insurance card. Never rely on your medical provider directory; pharmacy networks are separate. Always ask the pharmacy: “Is this pharmacy in-network for my prescription drug plan?”

Why is my out-of-network pharmacy bill so much higher?

In-network pharmacies have negotiated lower prices with your PBM. Out-of-network pharmacies charge the full retail price, and your plan may not cover any of it. For example, a $15 copay at an in-network pharmacy could become a $200+ out-of-pocket cost at an out-of-network one. There’s no cap or protection under federal law.

Can I get reimbursed if I paid out-of-network?

Sometimes - but don’t count on it. You can file a claim with your PBM and request a “reconsideration.” If you can prove you paid more than the plan’s negotiated rate, they may adjust your bill. Some PBMs will match the in-network price if you provide documentation. But many won’t reimburse you at all.

Are specialty medications more likely to be out-of-network?

Yes. Over 78% of Medicare Part D plans and 65% of commercial plans restrict specialty drugs - like those for cancer, MS, or rheumatoid arthritis - to specific specialty pharmacies. These are often mail-order or limited locations. If your drug is on this list, you may have no choice but to use one pharmacy - and if it’s out-of-network, you’re stuck with high costs.

What should I do if I can’t reach an in-network pharmacy?

Contact your PBM immediately. Ask if they can authorize an exception, waive the network requirement, or provide a temporary supply at a lower cost. If you’re in an emergency or rural area, they may make accommodations. Also, ask your doctor if there’s an alternative medication that’s covered at your local pharmacy.

3 Comments

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    Olivia Currie

    November 28, 2025 AT 21:20

    This hit me right in the feels. I paid $400 for my thyroid med last year because I didn’t check the network. I thought my insurance card = universal magic. Nope. Now I check before I even leave the house. Five minutes could save your rent money. 🙏

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    Curtis Ryan

    November 30, 2025 AT 10:33

    OMG YES. I just had this happen with my diabetes med. Went to the CVS near work, paid $220. Called my usual pharmacy 3 blocks away? $42. I felt like an idiot. But now I screenshot the network list before I even fill anything. Also, typo-prone here-sorry if I misspell ‘pharmacy’ again 😅

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    Rajiv Vyas

    November 30, 2025 AT 22:06

    Let’s be real-this isn’t a ‘surprise.’ It’s a scam. PBMs are middlemen who profit off confusion. Big Pharma owns them. Insurance companies are in on it. The ‘No Surprises Act’? A PR stunt. They let you die quietly from high copays while politicians take donations. Wake up. This is capitalism with a smiley face.

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